Anticholinergic drugs versus other medications for overactive bladder syndrome in adults

Review: anticholinergic drugs improve symptoms but increase dry mouth in adults with overactive bladder syndrome.

Study selection Randomised or quasi-randomised controlled trials in adults with symptomatic diagnosis of overactive bladder syndrome, urodynamic diagnosis of detrusor overactivity, or both, that compared an anticholinergic drug (given to decrease symptoms of overactive bladder) with placebo or no treatment. Studies of darifenacin, emepronium bromide or carrageenate, dicyclomine chloride, oxybut...

Gabapentin for overactive bladder and nocturia after anticholinergic failure.

INTRODUCTION We reviewed our experience with the use of gabapentin to treat symptoms of overactive bladder (OAB) and nocturia in patients who have failed conventional anticholinergic therapy. METHODS Thirty-one patients referred to us with refractory (OAB) and/or nocturia were treated with oral gabapentin. All the patients had tried or remained on antimuscarinic drugs during treatment. Twenty...

Anticholinergic Medications and Cognition in Older Adults

Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review.

OBJECTIVE To determine the effectiveness of anticholinergic drugs for the treatment of overactive bladder syndrome. DESIGN Systematic review of randomised controlled trials. DATA SOURCES Published papers and abstracts. STUDY SELECTION Randomised controlled trials with anticholinergic drug treatment in one arm and placebo in another. DATA EXTRACTION Primary outcomes of interest were pati...

Botulinum toxin outcomes for idiopathic overactive bladder stratified by indication: lack of anticholinergic efficacy versus intolerability.

AIMS To determine if the outcomes of intradetrusor botulinum toxin A (BTX-A) injections for the management of refractory overactive bladder (OAB) symptoms are different if performed due to lack of anticholinergic efficacy versus medication intolerability. METHODS Retrospective chart review was performed on all patients undergoing intradetrusor BTX-A (BOTOX®, Allergan Inc., Irvine, CA) injecti...